Development of a 3D ex vivo model of brain-leukemia interaction to study the role of activin A in the central nervous system microenvironment

Development of a 3D ex vivo model of brain-leukemia interaction to study the role of activin A in the central nervous system microenvironment

Abstract B-cell type acute lymphoblastic leukemia (B-ALL) is the most common type of childhood malignancy. Although the survival rate nowadays exceeds 90%, central nervous system (CNS) involvement is associated with a poor outcome. Experimental models are needed to study the interaction between leuk...

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Bibliographic Details
Main Authors: Erica Dander, Francesca Pischiutta, Noemi Di Marzo, Rosaria Pascente, Nicolò Panini, Alessandra Fallati, Andrea Biondi, Elisa R. Zanier, Giovanna D’Amico
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Acute lymphoblastic leukemia
Leukemia microenvironment
Organotypic brain slices
3-dimensional model
Activin A
Online Access:https://doi.org/10.1038/s41598-025-03877-w
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https://doi.org/10.1038/s41598-025-03877-w

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