Cell-death pathways and tau-associated neuronal vulnerability in Alzheimer’s disease

Cell-death pathways and tau-associated neuronal vulnerability in Alzheimer’s disease

Summary: Neuronal loss is the ultimate driver of neural system dysfunction in Alzheimer’s disease (AD). We used single-nucleus RNA sequencing and neuropathological phenotyping to elucidate mechanisms of neurodegeneration in AD by identifying vulnerable neuronal populations and probing for their diff...

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Main Authors: Gen Lin, Sarah E. Chancellor, Taekyung Kwon, Maya E. Woodbury, Astrid Doering, Aicha Abdourahman, Rachel E. Bennett, Fan Liao, Timothy Pastika, Joseph Tamm, Nandini Romanul, Kiran Yanamandra, Miwei Hu, Karen Zhao, Matthew P. Frosch, Yelena Grinberg, Huan Li, Sudeshna Das, Tammy Dellovade, Eric H. Karran, Robert V. Talanian, Knut Biber, Alberto Serrano-Pozo, Janina S. Ried, Xavier Langlois, Bradley T. Hyman
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Cell Reports
Subjects:
CP: Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725005297
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http://www.sciencedirect.com/science/article/pii/S2211124725005297

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