Receptor for Advanced Glycation Endproducts (RAGE), Its Ligands, and Soluble RAGE: Potential Biomarkers for Diagnosis and Therapeutic Targets for Human Renal Diseases
Receptor for advanced glycation endproducts (RAGE) is a multi-ligand receptor that is able to bind several different ligands, including advanced glycation endproducts, high-mobility group protein (B)1 (HMGB1), S-100 calcium-binding protein, amyloid-β-protein, Mac-1, and phosphatidylserine. Its inter...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BioMed Central
2013-12-01
|
| Series: | Genomics & Informatics |
| Subjects: | |
| Online Access: | http://genominfo.org/upload/pdf/gni-11-224.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832573897535389696 |
|---|---|
| author | Eun Ji Lee Jong Hoon Park |
| author_facet | Eun Ji Lee Jong Hoon Park |
| author_sort | Eun Ji Lee |
| collection | DOAJ |
| description | Receptor for advanced glycation endproducts (RAGE) is a multi-ligand receptor that is able to bind several different ligands, including advanced glycation endproducts, high-mobility group protein (B)1 (HMGB1), S-100 calcium-binding protein, amyloid-β-protein, Mac-1, and phosphatidylserine. Its interaction is engaged in critical cellular processes, such as inflammation, proliferation, apoptosis, autophagy, and migration, and dysregulation of RAGE and its ligands leads to the development of numerous human diseases. In this review, we summarize the signaling pathways regulated by RAGE and its ligands identified up to date and demonstrate the effects of hyper-activation of RAGE signals on human diseases, focused mainly on renal disorders. Finally, we propose that RAGE and its ligands are the potential targets for the diagnosis, monitoring, and treatment of numerous renal diseases. |
| format | Article |
| id | doaj-art-5c91b1e7991b4cdab534c33f853a7a65 |
| institution | Kabale University |
| issn | 1598-866X 2234-0742 |
| language | English |
| publishDate | 2013-12-01 |
| publisher | BioMed Central |
| record_format | Article |
| series | Genomics & Informatics |
| spelling | doaj-art-5c91b1e7991b4cdab534c33f853a7a652025-02-02T02:23:01ZengBioMed CentralGenomics & Informatics1598-866X2234-07422013-12-0111422422910.5808/GI.2013.11.4.22463Receptor for Advanced Glycation Endproducts (RAGE), Its Ligands, and Soluble RAGE: Potential Biomarkers for Diagnosis and Therapeutic Targets for Human Renal DiseasesEun Ji Lee0Jong Hoon Park1Department of Biological Science, Sookmyung Women's University, Seoul 140-742, Korea.Department of Biological Science, Sookmyung Women's University, Seoul 140-742, Korea.Receptor for advanced glycation endproducts (RAGE) is a multi-ligand receptor that is able to bind several different ligands, including advanced glycation endproducts, high-mobility group protein (B)1 (HMGB1), S-100 calcium-binding protein, amyloid-β-protein, Mac-1, and phosphatidylserine. Its interaction is engaged in critical cellular processes, such as inflammation, proliferation, apoptosis, autophagy, and migration, and dysregulation of RAGE and its ligands leads to the development of numerous human diseases. In this review, we summarize the signaling pathways regulated by RAGE and its ligands identified up to date and demonstrate the effects of hyper-activation of RAGE signals on human diseases, focused mainly on renal disorders. Finally, we propose that RAGE and its ligands are the potential targets for the diagnosis, monitoring, and treatment of numerous renal diseases.http://genominfo.org/upload/pdf/gni-11-224.pdfadvanced glycosylation end-product receptorkidney diseasessignal transduction |
| spellingShingle | Eun Ji Lee Jong Hoon Park Receptor for Advanced Glycation Endproducts (RAGE), Its Ligands, and Soluble RAGE: Potential Biomarkers for Diagnosis and Therapeutic Targets for Human Renal Diseases Genomics & Informatics advanced glycosylation end-product receptor kidney diseases signal transduction |
| title | Receptor for Advanced Glycation Endproducts (RAGE), Its Ligands, and Soluble RAGE: Potential Biomarkers for Diagnosis and Therapeutic Targets for Human Renal Diseases |
| title_full | Receptor for Advanced Glycation Endproducts (RAGE), Its Ligands, and Soluble RAGE: Potential Biomarkers for Diagnosis and Therapeutic Targets for Human Renal Diseases |
| title_fullStr | Receptor for Advanced Glycation Endproducts (RAGE), Its Ligands, and Soluble RAGE: Potential Biomarkers for Diagnosis and Therapeutic Targets for Human Renal Diseases |
| title_full_unstemmed | Receptor for Advanced Glycation Endproducts (RAGE), Its Ligands, and Soluble RAGE: Potential Biomarkers for Diagnosis and Therapeutic Targets for Human Renal Diseases |
| title_short | Receptor for Advanced Glycation Endproducts (RAGE), Its Ligands, and Soluble RAGE: Potential Biomarkers for Diagnosis and Therapeutic Targets for Human Renal Diseases |
| title_sort | receptor for advanced glycation endproducts rage its ligands and soluble rage potential biomarkers for diagnosis and therapeutic targets for human renal diseases |
| topic | advanced glycosylation end-product receptor kidney diseases signal transduction |
| url | http://genominfo.org/upload/pdf/gni-11-224.pdf |
| work_keys_str_mv | AT eunjilee receptorforadvancedglycationendproductsrageitsligandsandsolubleragepotentialbiomarkersfordiagnosisandtherapeutictargetsforhumanrenaldiseases AT jonghoonpark receptorforadvancedglycationendproductsrageitsligandsandsolubleragepotentialbiomarkersfordiagnosisandtherapeutictargetsforhumanrenaldiseases |