An antibody-drug conjugate targeting soluble and membrane-bound TGFα is effective against pancreatic tumors

Abstract Background Pancreatic cancer is one of the most difficult to treat neoplasias. Because of that, the prognosis of the disease is dismal, and identification of novel therapeutic approaches is needed. This study investigates the role of transforming growth factor-alpha (TGFα) in pancreatic can...

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Bibliographic Details
Main Authors: Inés Romero-Pérez, Juan Carlos Montero, Mónica Redondo-Puente, María del Carmen Gómez-García, Mireia Morell-Ginestà, Gabriel Capellá, Atanasio Pandiella
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Experimental & Clinical Cancer Research
Online Access:https://doi.org/10.1186/s13046-025-03421-8
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