The antimicrobial peptide Angie 5 inhibits TcdA and TcdB from Clostridioides difficile

The antimicrobial peptide Angie 5 inhibits TcdA and TcdB from Clostridioides difficile

Abstract Clostridioides (C.) difficile is a spore-forming, toxin-producing nosocomial human gut pathogen and a causative agent of gastrointestinal infections, leading to mild to severe diarrhea. Severe C. difficile infections (CDI) can cause life-threatening conditions, such as pseudomembranous coli...

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Main Authors: Stefanie Lietz, Lena-Marie Sokolowski, Katrin Lindner, Armando A. Rodríguez, Ludger Ständker, Verena Vogel, Barbara Spellerberg, Steffen Stenger, Daniel Alpízar-Pedraza, Katharina Ernst, Panagiotis Papatheodorou, Holger Barth
Format: Article
Language:English
Published: Springer 2025-06-01
Series:Cellular and Molecular Life Sciences
Subjects:
Clostridioides difficile
TcdA
TcdB
Toxin inhibitor
Endogenous proteins
Antimicrobial peptides
Online Access:https://doi.org/10.1007/s00018-025-05799-2
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https://doi.org/10.1007/s00018-025-05799-2

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