Mammalian Ste20-like kinase 1 regulates AMPK to mitigate the progression of non-alcoholic fatty liver disease

Mammalian Ste20-like kinase 1 regulates AMPK to mitigate the progression of non-alcoholic fatty liver disease

Abstract Background Non-alcoholic steatohepatitis (NASH) progression is strongly associated with deteriorating hepatic function, primarily driven by free cholesterol (FC) accumulation-induced lipotoxicity. Emerging evidence highlights the regulatory role of mammalian Ste20-like kinase 1 (MST1) in mo...

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Main Authors: Lijuan Wang, Chenglei Zhang, Jie Ma, Jiarui Li, Yuanyuan Wu, Yanru Ren, Jianning Li, Yan Li, Yi Yang
Format: Article
Language:English
Published: BMC 2025-04-01
Series:European Journal of Medical Research
Subjects:
Mammalian sterile 20-like kinase 1
AMP-activated protein kinase
Cholesterol synthesis
Hepatic free cholesterol
Non-alcoholic steatohepatitis
Online Access:https://doi.org/10.1186/s40001-025-02557-9
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https://doi.org/10.1186/s40001-025-02557-9

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