TRIM65 regulates glucose metabolic reprogramming to promote glioma cell proliferation via ubiquitination and degradation of AMPK
Abstract Glioma is the most common primary malignant brain tumor with high mortality and poor prognosis. Aerobic glycolysis is crucial for the malignant behavior of glioma by promoting their growth. Tripartite motif containing 65 (TRIM65) as an E3 ubiquitin ligase has been implicated in tumor progre...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-06-01
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| Series: | npj Precision Oncology |
| Online Access: | https://doi.org/10.1038/s41698-025-00964-z |
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