Downregulation of cGAS/STING expression in tumor cells by cancer-associated fibroblasts in colorectal cancer

Downregulation of cGAS/STING expression in tumor cells by cancer-associated fibroblasts in colorectal cancer

Abstract The tumor cell-intrinsic cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway is critical for activating anti-tumor immunity and enhancing immune checkpoint blockade therapy in colorectal cancer (CRC). Cancer-associated fibroblasts (CAFs), key components of the CRC...

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Main Authors: Ryo Kanoda, Shotaro Nakajima, Hirokazu Okayama, Akinao Kaneta, Shun Chida, Takuro Matsumoto, Katsuharu Saito, Tomohiro Kikuchi, Yuya Maruyama, Hiroya Suzuki, Kosaku Mimura, Motonobu Saito, Hiroyuki Hanayama, Wataru Sakamoto, Tomoyuki Momma, Zenichiro Saze, Koji Kono
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Subjects:
Colorectal cancer
Cancer-associated fibroblast
Versican
Tumor cell-intrinsic cGAS–STING
Online Access:https://doi.org/10.1038/s41598-025-03924-6
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https://doi.org/10.1038/s41598-025-03924-6

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