GLI1 regulates a novel neuropilin‐2/α6β1 integrin based autocrine pathway that contributes to breast cancer initiation

GLI1 regulates a novel neuropilin‐2/α6β1 integrin based autocrine pathway that contributes to breast cancer initiation

Abstract The characterization of cells with tumour initiating potential is significant for advancing our understanding of cancer and improving therapy. Aggressive, triple‐negative breast cancers (TNBCs) are enriched for tumour‐initiating cells (TICs). We investigated that hypothesis that VEGF recept...

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Main Authors: Hira Lal Goel, Bryan Pursell, Cheng Chang, Leslie M. Shaw, Junhao Mao, Karl Simin, Prashant Kumar, Craig W. Vander Kooi, Leonard D. Shultz, Dale L. Greiner, Jens Henrik Norum, Rune Toftgard, Charlotte Kuperwasser, Arthur M. Mercurio
Format: Article
Language:English
Published: Springer Nature 2013-02-01
Series:EMBO Molecular Medicine
Subjects:
breast cancer
GLI1
integrin
neuropilin‐2
stem cells
Online Access:https://doi.org/10.1002/emmm.201202078
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https://doi.org/10.1002/emmm.201202078

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