Discovery of thiazostatin D/E using UPLC-HR-MS2-based metabolomics and σ-factor engineering of Actinoplanes sp. SE50/110

Discovery of thiazostatin D/E using UPLC-HR-MS2-based metabolomics and σ-factor engineering of Actinoplanes sp. SE50/110

As the natural producer of acarbose, Actinoplanes sp. SE50/110 has high industrial relevance. Like most Actinobacteria, the strain carries several more putative biosynthetic gene clusters (BGCs) to produce further natural products, which are to be discovered. Applying a metabolomics-guided approach,...

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Bibliographic Details
Main Authors: Laura Schlüter, Kine Østnes Hansen, Johan Isaksson, Jeanette Hammer Andersen, Espen Holst Hansen, Jörn Kalinowski, Yannik Karl-Heinz Schneider
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
Actinobacteria
Actinoplanes sp. SE50/110
natural products
secondary metabolites
sigma factor
hydroxyphenylthiazoline
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2024.1497138/full
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https://www.frontiersin.org/articles/10.3389/fbioe.2024.1497138/full

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