The Role of C1-Esterase Inhibitors in the Management of Vasogenic Edema in Glioblastoma
Glioblastoma (GB) is one of the most common adult primary brain tumors, classified as a grade IV astrocytoma and highly malignant in nature. As the tumor grows and disrupts the blood-brain barrier (BBB), vasogenic edema can result. The edema has the potential to significantly contribute to a patient...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2020/7981609 |
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| author | Gillian R. Naro Nicholas Noverati Timothy Craig |
| author_facet | Gillian R. Naro Nicholas Noverati Timothy Craig |
| author_sort | Gillian R. Naro |
| collection | DOAJ |
| description | Glioblastoma (GB) is one of the most common adult primary brain tumors, classified as a grade IV astrocytoma and highly malignant in nature. As the tumor grows and disrupts the blood-brain barrier (BBB), vasogenic edema can result. The edema has the potential to significantly contribute to a patient’s morbidity and mortality. Bradykinin has been theorized to play a role in this process as well as encourage tumor spread. Here we discuss a case in which a patient with vasogenic edema and angioedema refractory to antihistamines and high dose corticosteroids responded to C1-esterase inhibitor (C1INH) therapy. Though data exist concerning the role of bradykinin in GB, no clinical studies using C1INH have been done in humans with GB. |
| format | Article |
| id | doaj-art-5c4a901c62f64829a4b46feae851139c |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-5c4a901c62f64829a4b46feae851139c2025-02-03T01:05:17ZengWileyCase Reports in Medicine1687-96271687-96352020-01-01202010.1155/2020/79816097981609The Role of C1-Esterase Inhibitors in the Management of Vasogenic Edema in GlioblastomaGillian R. Naro0Nicholas Noverati1Timothy Craig2Penn State University College of Medicine, Hershey, PA, USAPenn State University College of Medicine, Hershey, PA, USAPenn State University College of Medicine, Hershey, PA, USAGlioblastoma (GB) is one of the most common adult primary brain tumors, classified as a grade IV astrocytoma and highly malignant in nature. As the tumor grows and disrupts the blood-brain barrier (BBB), vasogenic edema can result. The edema has the potential to significantly contribute to a patient’s morbidity and mortality. Bradykinin has been theorized to play a role in this process as well as encourage tumor spread. Here we discuss a case in which a patient with vasogenic edema and angioedema refractory to antihistamines and high dose corticosteroids responded to C1-esterase inhibitor (C1INH) therapy. Though data exist concerning the role of bradykinin in GB, no clinical studies using C1INH have been done in humans with GB.http://dx.doi.org/10.1155/2020/7981609 |
| spellingShingle | Gillian R. Naro Nicholas Noverati Timothy Craig The Role of C1-Esterase Inhibitors in the Management of Vasogenic Edema in Glioblastoma Case Reports in Medicine |
| title | The Role of C1-Esterase Inhibitors in the Management of Vasogenic Edema in Glioblastoma |
| title_full | The Role of C1-Esterase Inhibitors in the Management of Vasogenic Edema in Glioblastoma |
| title_fullStr | The Role of C1-Esterase Inhibitors in the Management of Vasogenic Edema in Glioblastoma |
| title_full_unstemmed | The Role of C1-Esterase Inhibitors in the Management of Vasogenic Edema in Glioblastoma |
| title_short | The Role of C1-Esterase Inhibitors in the Management of Vasogenic Edema in Glioblastoma |
| title_sort | role of c1 esterase inhibitors in the management of vasogenic edema in glioblastoma |
| url | http://dx.doi.org/10.1155/2020/7981609 |
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