Functional Characterization of LTR12C as Regulators of Germ-Cell-Associated TA-p63 in U87-MG and T98-G In Vitro Models

Functional Characterization of LTR12C as Regulators of Germ-Cell-Associated TA-p63 in U87-MG and T98-G In Vitro Models

Glioblastoma multiforme (GBM) is a deadly disease known for its genetic heterogeneity. LTR12C is an endogenous retrovirus-derived regulator of pro-apoptotic genes and is normally silenced by epigenetic regulation. In this study, we found that the treatment of two glioblastoma cell lines, T98-G and U...

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Bibliographic Details
Main Authors: Lucia Meola, Sohum Rajesh Shetty, Angelo Peschiaroli, Claudio Sette, Camilla Bernardini
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Cells
Subjects:
epigenetics
LTR12C
glioblastoma
GTA-p63
p21
Online Access:https://www.mdpi.com/2073-4409/14/11/852
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