Translational horizons in stem cell therapy for osteonecrosis of the femoral head: a journey from basic research to clinical practice through bibliometric insights
Abstract Background Osteonecrosis of the femoral head (ONFH) significantly impacts young and middle-aged adults, with steroid use implicated in many cases. Traditional treatments have limited efficacy, prompting a shift towards innovative approaches, such as stem cell therapy, offering less invasive...
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BMC
2024-10-01
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| Series: | Journal of Translational Medicine |
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| Online Access: | https://doi.org/10.1186/s12967-024-05784-6 |
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| author | Tingyu Wu Yinxue Zhou Weipeng Shi Sijia Guo Hua Tian Weiyan Li Yingzhen Wang Tao Li |
| author_facet | Tingyu Wu Yinxue Zhou Weipeng Shi Sijia Guo Hua Tian Weiyan Li Yingzhen Wang Tao Li |
| author_sort | Tingyu Wu |
| collection | DOAJ |
| description | Abstract Background Osteonecrosis of the femoral head (ONFH) significantly impacts young and middle-aged adults, with steroid use implicated in many cases. Traditional treatments have limited efficacy, prompting a shift towards innovative approaches, such as stem cell therapy, offering less invasive regenerative solutions. Methods Using bibliometric analysis from 1997 to 2023, we identified 392 articles on stem cell therapy for ONFH from the Web of Science Core Collection and analysed them using VOSviewer and CiteSpace to identify key trends and research directions. Results From 1997 to 2023, stem cell therapy for ONFH research expanded significantly, with 392 articles evidencing global collaboration, particularly from China, the United States and South Korea. The field is characterised by 158 core authors across 26 clusters and contributions from 417 institutions in 104 research clusters, with Shanghai Jiao Tong University as a notable leader. This research is disseminated through 23 journal clusters, emphasising interdisciplinary work, with Clinical Orthopaedics and Related Research among the most influential journals. Key findings include the identification of the most influential papers, highlighting advances, such as use of autologous mesenchymal stem cells (MSCs) and innovative delivery mechanisms. High-frequency keyword analysis further mapped the evolution of the field, from basic mechanisms to advanced therapies, underscoring a trend towards more targeted stem cell treatments for ONFH. Conclusion Stem cell therapy for ONFH has advanced significantly, showcasing a successful transition from basic research to clinical practice, particularly highlighted by developments in use of autologous MSCs and delivery methods. Future research will focus on refining therapies through exosome technology, targeted modulation of stress and inflammation and integration with surgical techniques, with the aim of tailored patient care and improved ONFH outcomes. |
| format | Article |
| id | doaj-art-5c2eebcbbff24edd9efea9aee2eba3ec |
| institution | OA Journals |
| issn | 1479-5876 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj-art-5c2eebcbbff24edd9efea9aee2eba3ec2025-08-20T02:18:25ZengBMCJournal of Translational Medicine1479-58762024-10-0122111810.1186/s12967-024-05784-6Translational horizons in stem cell therapy for osteonecrosis of the femoral head: a journey from basic research to clinical practice through bibliometric insightsTingyu Wu0Yinxue Zhou1Weipeng Shi2Sijia Guo3Hua Tian4Weiyan Li5Yingzhen Wang6Tao Li7Department of Joint Surgery, The Affiliated Hospital of Qingdao UniversityDepartment of Respiratory and Critical Care Medicine, The Affiliated Hospital of Qingdao UniversityDepartment of Joint Surgery, The Affiliated Hospital of Qingdao UniversityDepartment of Joint Surgery, The Affiliated Hospital of Qingdao UniversityDepartment of Neurological Rehabilitation, Qingdao Special Servicemen Recuperation Center of PLA NavyDepartment of Emergency Surgery and Joint Surgery, Qingdao Third People’s HospitalDepartment of Joint Surgery, The Affiliated Hospital of Qingdao UniversityDepartment of Joint Surgery, The Affiliated Hospital of Qingdao UniversityAbstract Background Osteonecrosis of the femoral head (ONFH) significantly impacts young and middle-aged adults, with steroid use implicated in many cases. Traditional treatments have limited efficacy, prompting a shift towards innovative approaches, such as stem cell therapy, offering less invasive regenerative solutions. Methods Using bibliometric analysis from 1997 to 2023, we identified 392 articles on stem cell therapy for ONFH from the Web of Science Core Collection and analysed them using VOSviewer and CiteSpace to identify key trends and research directions. Results From 1997 to 2023, stem cell therapy for ONFH research expanded significantly, with 392 articles evidencing global collaboration, particularly from China, the United States and South Korea. The field is characterised by 158 core authors across 26 clusters and contributions from 417 institutions in 104 research clusters, with Shanghai Jiao Tong University as a notable leader. This research is disseminated through 23 journal clusters, emphasising interdisciplinary work, with Clinical Orthopaedics and Related Research among the most influential journals. Key findings include the identification of the most influential papers, highlighting advances, such as use of autologous mesenchymal stem cells (MSCs) and innovative delivery mechanisms. High-frequency keyword analysis further mapped the evolution of the field, from basic mechanisms to advanced therapies, underscoring a trend towards more targeted stem cell treatments for ONFH. Conclusion Stem cell therapy for ONFH has advanced significantly, showcasing a successful transition from basic research to clinical practice, particularly highlighted by developments in use of autologous MSCs and delivery methods. Future research will focus on refining therapies through exosome technology, targeted modulation of stress and inflammation and integration with surgical techniques, with the aim of tailored patient care and improved ONFH outcomes.https://doi.org/10.1186/s12967-024-05784-6Basic researchBibliometricClinical practiceOsteonecrosis of the femoral headStem cell therapy |
| spellingShingle | Tingyu Wu Yinxue Zhou Weipeng Shi Sijia Guo Hua Tian Weiyan Li Yingzhen Wang Tao Li Translational horizons in stem cell therapy for osteonecrosis of the femoral head: a journey from basic research to clinical practice through bibliometric insights Journal of Translational Medicine Basic research Bibliometric Clinical practice Osteonecrosis of the femoral head Stem cell therapy |
| title | Translational horizons in stem cell therapy for osteonecrosis of the femoral head: a journey from basic research to clinical practice through bibliometric insights |
| title_full | Translational horizons in stem cell therapy for osteonecrosis of the femoral head: a journey from basic research to clinical practice through bibliometric insights |
| title_fullStr | Translational horizons in stem cell therapy for osteonecrosis of the femoral head: a journey from basic research to clinical practice through bibliometric insights |
| title_full_unstemmed | Translational horizons in stem cell therapy for osteonecrosis of the femoral head: a journey from basic research to clinical practice through bibliometric insights |
| title_short | Translational horizons in stem cell therapy for osteonecrosis of the femoral head: a journey from basic research to clinical practice through bibliometric insights |
| title_sort | translational horizons in stem cell therapy for osteonecrosis of the femoral head a journey from basic research to clinical practice through bibliometric insights |
| topic | Basic research Bibliometric Clinical practice Osteonecrosis of the femoral head Stem cell therapy |
| url | https://doi.org/10.1186/s12967-024-05784-6 |
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