Subcutaneous BCG vaccination protects against streptococcal pneumonia via regulating innate immune responses in the lung

Subcutaneous BCG vaccination protects against streptococcal pneumonia via regulating innate immune responses in the lung

Abstract Bacillus Calmette‐Guérin (BCG) still remains the only licensed vaccine for TB and has been shown to provide nonspecific protection against unrelated pathogens. This has been attributed to the ability of BCG to modulate the innate immune system, known as trained innate immunity (TII). Traine...

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Main Authors: Alisha Kang, Gluke Ye, Ramandeep Singh, Sam Afkhami, Jegarubee Bavananthasivam, Xiangqian Luo, Maryam Vaseghi‐Shanjani, Fatemah Aleithan, Anna Zganiacz, Mangalakumari Jeyanathan, Zhou Xing
Format: Article
Language:English
Published: Springer Nature 2023-05-01
Series:EMBO Molecular Medicine
Subjects:
lung
Streptococcus pneumoniae infection
subcutaneous BCG vaccine
tissue‐resident macrophages
trained innate immunity
Online Access:https://doi.org/10.15252/emmm.202217084
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https://doi.org/10.15252/emmm.202217084

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