Identification of the seven critical residues that control ZIKV-DENV cross-reactivity to engineer a non-cross-reactive ZIKV vaccine

Identification of the seven critical residues that control ZIKV-DENV cross-reactivity to engineer a non-cross-reactive ZIKV vaccine

Summary: The development of a Zika virus (ZIKV) vaccine is complicated by the high homology between ZIKV and dengue virus (DENV) envelope (E) proteins, resulting in immunological cross-reactivity that can exacerbate disease through antibody-dependent enhancement (ADE). Here, we screen 121 anti-DENV...

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Main Authors: Ariadna Grinyo-Escuer, Srikar Reddy, Agnes L. Chenine, J. Charles Whitbeck, Sonya Jacobsen, Allison Sheetz, Kyle Doolan, Diana M. Norden, Nolan Frey, Frederick W. Holtsberg, M. Javad Aman, Katja Fink, Michael S. Diamond, John S. Schieffelin, James E. Crowe, Jr., Edgar Davidson, Benjamin J. Doranz
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Cell Reports
Subjects:
CP: Immunology
CP: Microbiology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725008691
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