Real-world effectiveness and safety of prolonged bedaquiline course in the treatment of drug-resistant tuberculosis—a multi-center retrospective cohort study in a country with a high burden of drug-resistant tuberculosis

Real-world effectiveness and safety of prolonged bedaquiline course in the treatment of drug-resistant tuberculosis—a multi-center retrospective cohort study in a country with a high burden of drug-resistant tuberculosis

ABSTRACT Bedaquiline (BDQ) has gradually become a core drug in drug-resistant tuberculosis (DR-TB) treatment, and the additional benefits of prolonging BDQ use remain unclear. Patients with DR-TB who received a BDQ-containing regimen from three Chinese clinical centers between 1 March 2018 and 31 De...

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Main Authors: Yuanyuan Yu, Jie Cao, Hongqiu Pan, Hui Zhong, Xiaocui Wu, Jinghui Yang, Liping Cheng, Qingrong Qu, Lei Wang, Fuhui Lu, Hongyu Chen, Jie Wang, Wei Sha, Qin Sun
Format: Article
Language:English
Published: American Society for Microbiology 2025-08-01
Series:Microbiology Spectrum
Subjects:
prolonged
bedaquiline
effectiveness
safety
propensity score match (PSM)
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00097-25
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https://journals.asm.org/doi/10.1128/spectrum.00097-25

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