The IL-33/ST2 axis and tissue Treg maintain epithelial homeostasis and restrain cancer development in the skin

The IL-33/ST2 axis and tissue Treg maintain epithelial homeostasis and restrain cancer development in the skin

Summary: Interleukin (IL)-33 is constitutively expressed in many epithelial tissues at steady state and signals through the receptor, ST2. IL-33 is released upon tissue injury and functions as an endogenous danger signal to alert the immune system to tissue damage. Here we investigate the physiologi...

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Main Authors: Sophie Ward, Greg Crawford, Buang Norzawani, Christina Malactou, Emma Dutton, Isabella Withnell, Kevin J. Woollard, Catherine Harwood, Henry J. McSorley, Christoph Ziegenhain, Adrian Lärkeryd, Anguraj Sadanandam, Jessica Strid
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Cell Reports
Subjects:
CP: Cancer
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725006084
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http://www.sciencedirect.com/science/article/pii/S2211124725006084

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