Transcriptomic signatures of oxytosis/ferroptosis are enriched in Alzheimer’s disease

Transcriptomic signatures of oxytosis/ferroptosis are enriched in Alzheimer’s disease

Abstract Background Oxytosis/ferroptosis is a form of non-apoptotic regulated cell death characterized by specific changes in the redox balance that lead to lethal lipid peroxidation. It has been hypothesized recently that aging predisposes the brain to the activation of oxytosis/ferroptosis in Alzh...

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Bibliographic Details
Main Authors: Antonio Currais, Kayla Sanchez, David Soriano-Castell, Nawab John Dar, K. Garrett Evensen, Salvador Soriano, Pamela Maher
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Biology
Subjects:
Oxytosis/ferroptosis
Alzheimer’s disease
Transcriptomics
Integrated stress response (ISR)
Activating transcription factor 4 (ATF4)
Online Access:https://doi.org/10.1186/s12915-025-02235-6
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https://doi.org/10.1186/s12915-025-02235-6

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