Splenic macrophage functional profile and its role in the immunopathogenesis of canine visceral leishmaniasis

Splenic macrophage functional profile and its role in the immunopathogenesis of canine visceral leishmaniasis

IntroductionVisceral leishmaniasis (VL) represents a major public health challenge, with the spleen frequently identified as one of the primary target organs. Dogs recognized as urban reservoir hosts, commonly harbor chronic infections characterized by elevated parasite burdens across multiple tissu...

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Main Authors: Tainã Luís de Souza, Marta de Almeida Santiago, Francini Neves Ribeiro, Fabiano Borges Figueiredo, Artur Augusto Velho Mendes Junior, Rodrigo Caldas Menezes, Renato Porrozzi, Fernanda Nazaré Morgado
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
visceral leishmaniasis
dog
cell exhaustion
macrophage
spleen
M1 macrophages
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1617751/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1617751/full

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