Intrapatient tacrolimus variability is associated with medical nonadherence among pediatric kidney transplant recipients

Intrapatient tacrolimus variability is associated with medical nonadherence among pediatric kidney transplant recipients

BackgroundLong-term survival of kidney allografts is limited by multiple factors, including nonadherence. High intrapatient variability in tacrolimus levels (≥30%) is associated with de novo donor-specific antibody (dnDSA) formation, increased risk of rejection and graft loss.MethodsWe prospectively...

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Bibliographic Details
Main Authors: Tara B. Gavcovich, Vaka K. Sigurjonsdottir, Marissa J. DeFreitas, Claudia Serrano, Esther Rivas, Migdalia Jorge, Wacharee Seeherunvong, Chryso Katsoufis, Wendy Glaberson, Melisa Oliva, Adela D. Mattiazzi, Carolyn Abitbol, Jayanthi Chandar
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Transplantation
Subjects:
kidney transplant
pediatric
adherence
tacrolimus variability
tacrolimus
pediatric kidney transplant recipients
Online Access:https://www.frontiersin.org/articles/10.3389/frtra.2025.1572928/full
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https://www.frontiersin.org/articles/10.3389/frtra.2025.1572928/full

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