A VersaTile Approach to Reprogram the Specificity of the R2-Type Tailocin Towards Different Serotypes of <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i>

A VersaTile Approach to Reprogram the Specificity of the R2-Type Tailocin Towards Different Serotypes of <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i>

<b>Background:</b> Phage tail-like bacteriocins, or tailocins, provide a competitive advantage to producer cells by killing closely related bacteria. Morphologically similar to headless phages, their narrow target specificity is determined by receptor-binding proteins (RBPs). While RBP e...

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Bibliographic Details
Main Authors: Dorien Dams, Célia Pas, Agnieszka Latka, Zuzanna Drulis-Kawa, Lars Fieseler, Yves Briers
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Antibiotics
Subjects:
tailocin
phage tail-like bacteriocin
R2 pyocin
<i>Klebsiella pneumoniae</i>
<i>Escherichia coli</i>
receptor-binding protein
Online Access:https://www.mdpi.com/2079-6382/14/1/104
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