Temporal dynamics of the vaginal microbiome and host immune markers before, during, and after metronidazole treatment for bacterial vaginosis

Temporal dynamics of the vaginal microbiome and host immune markers before, during, and after metronidazole treatment for bacterial vaginosis

ABSTRACT This study analyzed metagenomic and immune marker profiles of seven individuals before, during, and after a 7-day course of metronidazole treatment for bacterial vaginosis (BV). Treatment reduced BV-associated bacteria and immune marker levels, with distinct early (days 1–4) and late (days...

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Bibliographic Details
Main Authors: Amanda Williams, Jacques Ravel, Eric Armstrong, Sanja Huibner, Lindsay Rutt, Rupert Kaul, Johanna B. Holm
Format: Article
Language:English
Published: American Society for Microbiology 2025-07-01
Series:mSystems
Subjects:
vaginal microbiota
vaginal dysbiosis
antibiotics
metagenome
inflammatory markers
Online Access:https://journals.asm.org/doi/10.1128/msystems.00380-25
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https://journals.asm.org/doi/10.1128/msystems.00380-25

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