Improving drug repositioning accuracy using non-negative matrix tri-factorization

Abstract Drug repositioning is a transformative approach in drug discovery, offering a pathway to repurpose existing drugs for new therapeutic uses. In this study, we introduce the IDDNMTF model designed to predict drug repositioning opportunities with greater precision. The IDDNMTF model integrates...

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Bibliographic Details
Main Authors: Qingmei Li, Yangyang Wang, Jihan Wang, Congzhe Zhao
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Online Access:https://doi.org/10.1038/s41598-025-91757-8
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