Identification of modulators of the ALT pathway through a native FISH-based optical screen

Identification of modulators of the ALT pathway through a native FISH-based optical screen

Summary: A significant portion of human cancers utilize a recombination-based pathway, alternative lengthening of telomeres (ALT), to extend telomeres. To gain further insights into this pathway, we developed a high-throughput imaging-based screen named TAILS (telomeric ALT in situ localization scre...

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Main Authors: Benura Azeroglu, Simran Khurana, Shih-Chun Wang, Gianna M. Tricola, Shalu Sharma, Camille Jubelin, Ylenia Cortolezzis, Gianluca Pegoraro, Kyle M. Miller, Travis H. Stracker, Eros Lazzerini Denchi
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Cell Reports
Subjects:
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724014657
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