Sex-differentiated placental methylation and gene expression regulation has implications for neonatal traits and adult diseases

Abstract Sex differences in physiological and disease traits are pervasive and begin during early development, but the genetic architecture of these differences is largely unknown. Here, we leverage the human placenta, a transient organ during pregnancy critical to fetal development, to investigate...

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Bibliographic Details
Main Authors: Fasil Tekola-Ayele, Richard J. Biedrzycki, Tesfa Dejenie Habtewold, Prabhavi Wijesiriwardhana, Amber Burt, Carmen J. Marsit, Marion Ouidir, Ronald Wapner
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58128-3
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