Balancing inflammation: the specific roles of serum amyloid A proteins in sterile and infectious diseasese

Balancing inflammation: the specific roles of serum amyloid A proteins in sterile and infectious diseasese

Serum Amyloid A (SAA) proteins are acute-phase reactants with critical roles in sterile and bacterial inflammation. Through in vitro and in vivo experiments, we demonstrate that SAA proteins amplify cytokine and chemokine responses during sterile inflammation and enhance bacterial clearance in infec...

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Bibliographic Details
Main Authors: Tirthankar Mohanty, Katarina Miličević, Henri Göthert, Andreas Tillmann, Médea Padra, Praveen Papareddy, Heiko Herwald
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Immunology
Subjects:
innate immunity
PAMPs (pathogen associated molecular patterns)
inflammation
serum amyloid proteins
cytokines
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1544085/full
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