GalNT2-mediated O-glycosylation affects pancreas development and function in mice

GalNT2-mediated O-glycosylation affects pancreas development and function in mice

Abstract GALNT2, also known as polypeptide N-acetylgalactosaminyltransferase 2, is an enzyme that catalyzes the initial step of O-linked glycosylation, a crucial posttranslational modification that affects protein folding, stability, and function. Alterations in GALNT2 activity have been implicated...

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Main Authors: Baris Mercanoglu, Sissy-Alina Waschkowski, Elena Neuburg, Nina Schraps, Anastasios D. Giannou, Benjamin Dreyer, Sönke Harder, Markus Heine, Christian F. Krebs, Cenap Güngör, Hartmut Schlüter, Nathaniel Melling, Thilo Hackert, Maximilian Bockhorn, Christoph Wagener, Gerrit Wolters-Eisfeld
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
GalNT2
O-glycosylation
Pancreas
Atrophy
Pancreatic steatosis
Online Access:https://doi.org/10.1038/s41598-024-80276-7
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https://doi.org/10.1038/s41598-024-80276-7

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