Deciphering the role of CAPZA2 in neurodevelopmental disorders: insights from mouse models

Abstract Intellectual disability affects 1–3% of the global population, with many unidentified genetic causes. This study investigates the role of CAPZA2, an actin cytoskeleton regulator, in neurodevelopmental disorders using CAPZA2 heterozygous knockout (CAPZA2+/−) and heterozygous point mutant (CA...

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Bibliographic Details
Main Authors: Mei Guo, Liming Liu, Xiao Mao, Manyu Xiao, Xiaobin He, Xing Pan, Yuewen Chen, Wanying Yi, Qibin Li, Xianglan Piao, Hua Wang, Yang Du, Yong Cheng
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08385-1
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