Transcription factor ZNF266 suppresses cancer progression by modulating CA9-mediated intracellular pH alteration in lung adenocarcinoma

Transcription factor ZNF266 suppresses cancer progression by modulating CA9-mediated intracellular pH alteration in lung adenocarcinoma

Abstract Background Lung cancer remains the leading cause of cancer-related mortality globally, with lung adenocarcinoma (LUAD) being the most prevalent subtype. Despite extensive research efforts, the role of transcription factors in LUAD progression remains largely uncharacterized. In this study,...

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Main Authors: Shencheng Ren, Junkan Zhu, Guangyao Shan, Jiaqi Liang, Yunyi Bian, Han Lin, Haochun Shi, Binyang Pan, Guangyin Zhao, Huiqin Yang, Xiaolong Huang, Cheng Zhan, Di Ge, Guoshu Bi
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Respiratory Research
Subjects:
Transcription factor
Lung adenocarcinoma
Intracellular pH
mTOR
Organoids
Online Access:https://doi.org/10.1186/s12931-025-03278-7
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https://doi.org/10.1186/s12931-025-03278-7

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