BEZ235-Mediated PI3K/mTOR dual inhibition improves ovarian follicle survival in a preclinical model

BEZ235-Mediated PI3K/mTOR dual inhibition improves ovarian follicle survival in a preclinical model

Abstract Background Follicular loss after ovarian tissue cryopreservation and autotransplantation (OTCTP) remains a major challenge due to follicle activation and ischemia. We evaluated BEZ235, a dual PI3K/mTOR inhibitor, as a strategy to improve follicle survival in a preclinical model. Its effects...

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Bibliographic Details
Main Authors: Jules Bindels, Laëtitia Bernet, Marlyne Squatrito, Michelle Nisolle, Carine Munaut
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Reproductive Biology and Endocrinology
Subjects:
Follicle activation
Ovarian tissue cryopreservation
Fertility preservation
Ovarian transplantation
Organotypic ovarian culture
PI3K/PTEN/Akt signaling
Online Access:https://doi.org/10.1186/s12958-025-01427-7
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https://doi.org/10.1186/s12958-025-01427-7

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