Air-liquid interface culture alters the characteristics and functions of monolayers generated from human iPS cell‑derived enterocyte‑like cell organoids

Air-liquid interface culture alters the characteristics and functions of monolayers generated from human iPS cell‑derived enterocyte‑like cell organoids

To evaluate the intestinal absorption and metabolism of orally administered drugs, human induced pluripotent stem (iPS) cell‑derived enterocyte‑like cells (ELCs) are expected to be useful. In a previous report, we succeeded in developing a highly functional monolayer platform (ELC-org-mono) from hum...

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Bibliographic Details
Main Authors: Tatsuya Inui, Yusei Uraya, Yukiko Ueyama-Toba, Hiroyuki Mizuguchi
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:European Journal of Cell Biology
Subjects:
Intestinal organoids
Small intestine
IPS cell
Drug-metabolizing enzymes
Drug transporters
Online Access:http://www.sciencedirect.com/science/article/pii/S0171933525000044
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