TCR-T cell therapy: current development approaches, preclinical evaluation, and perspectives on regulatory challenges

TCR-T cell therapy: current development approaches, preclinical evaluation, and perspectives on regulatory challenges

Abstract TCR-T cell therapy represents a promising advancement in adoptive immunotherapy for cancer treatment. Despite its potential, the development and preclinical testing of TCR-T cells face significant challenges. This review provides a structured overview of the key stages in preclinical testin...

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Bibliographic Details
Main Authors: Elena A. Golikova, Alina A. Alshevskaya, Saleh Alrhmoun, Natalia A. Sivitskaya, Sergey V. Sennikov
Format: Article
Language:English
Published: BMC 2024-10-01
Series:Journal of Translational Medicine
Subjects:
Immune engineering
TCR-T-cell therapy
Guideline systematization
Adoptive immunotherapy
T cell receptor
Cancer Immunotherapy
Online Access:https://doi.org/10.1186/s12967-024-05703-9
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https://doi.org/10.1186/s12967-024-05703-9

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