Tetrahydropyrido[4,3-d]pyrimidines as a new active scaffold for human topoisomerase II inhibitors

Tetrahydropyrido[4,3-d]pyrimidines as a new active scaffold for human topoisomerase II inhibitors

Abstract Human topoisomerase II (topoII) is a well-known and validated target for cancer treatment. We previously reported a first set of 6-amino-tetrahydroquinazoline derivatives as novel human topoII inhibitors. Here, we report on the expansion and this molecular scaffold and present 17 additional...

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Main Authors: Nicoletta Brindani, Maria Antonietta La Serra, Jose Antonio Ortega, Jose M. Arencibia, Michela Nigro, Sine Mandrup Bertozzi, Andrea Armirotti, Marco Borgogno, Claudia Sissi, Marco De Vivo
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Subjects:
Topoisomerase II inhibitors
Cancer treatment
Tetrahydropyridopyrimidines derivatives.
Online Access:https://doi.org/10.1038/s41598-025-04773-z
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https://doi.org/10.1038/s41598-025-04773-z

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