Stereoselectivity in Enzymic Biotransformation of Chiral and Achiral 1,3-Dihydro-2H-1,4-Benzodiazepin-2-ones
Enzymic biotransformation of chiral 1,4-benzodiazepin-2-ones (S and R forms) is found to be configuration dependent for hydroxylation in aromatic rings, but hydroxylation in position 3, as well as N1-demethylation prooved to be nonstereospecific.
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | deu |
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Swiss Chemical Society
1974-05-01
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| Series: | CHIMIA |
| Online Access: | https://www.chimia.ch/chimia/article/view/9140 |
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| _version_ | 1849310953678569472 |
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| author | S. Rendić V. Šunjić F. Kajfež L. Klasinc P. Mildner |
| author_facet | S. Rendić V. Šunjić F. Kajfež L. Klasinc P. Mildner |
| author_sort | S. Rendić |
| collection | DOAJ |
| description |
Enzymic biotransformation of chiral 1,4-benzodiazepin-2-ones (S and R forms) is found to be configuration dependent for hydroxylation in aromatic rings, but hydroxylation in position 3, as well as N1-demethylation prooved to be nonstereospecific.
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| format | Article |
| id | doaj-art-5b584d6b915040f8a4dba60dc9e0d7de |
| institution | Kabale University |
| issn | 0009-4293 2673-2424 |
| language | deu |
| publishDate | 1974-05-01 |
| publisher | Swiss Chemical Society |
| record_format | Article |
| series | CHIMIA |
| spelling | doaj-art-5b584d6b915040f8a4dba60dc9e0d7de2025-08-20T03:53:33ZdeuSwiss Chemical SocietyCHIMIA0009-42932673-24241974-05-0128510.2533/chimia.1974.232Stereoselectivity in Enzymic Biotransformation of Chiral and Achiral 1,3-Dihydro-2H-1,4-Benzodiazepin-2-onesS. Rendić0V. Šunjić1F. Kajfež2L. Klasinc3P. Mildner4CRC (Compagnia di Ricerca Chimica), CH-6830 Chiasso (Switzerland); Institute of Organic Chemistry and Biochemistry, Zagreb (Yugoslavia)CRC (Compagnia di Ricerca Chimica), CH-6830 Chiasso (Switzerland); Institute of Organic Chemistry and Biochemistry, Zagreb (Yugoslavia)CRC (Compagnia di Ricerca Chimica), CH-6830 Chiasso (Switzerland); Institute of Organic Chemistry and Biochemistry, Zagreb (Yugoslavia)CRC (Compagnia di Ricerca Chimica), CH-6830 Chiasso (Switzerland); Institute of Organic Chemistry and Biochemistry, Zagreb (Yugoslavia)CRC (Compagnia di Ricerca Chimica), CH-6830 Chiasso (Switzerland); Institute of Organic Chemistry and Biochemistry, Zagreb (Yugoslavia) Enzymic biotransformation of chiral 1,4-benzodiazepin-2-ones (S and R forms) is found to be configuration dependent for hydroxylation in aromatic rings, but hydroxylation in position 3, as well as N1-demethylation prooved to be nonstereospecific. https://www.chimia.ch/chimia/article/view/9140 |
| spellingShingle | S. Rendić V. Šunjić F. Kajfež L. Klasinc P. Mildner Stereoselectivity in Enzymic Biotransformation of Chiral and Achiral 1,3-Dihydro-2H-1,4-Benzodiazepin-2-ones CHIMIA |
| title | Stereoselectivity in Enzymic Biotransformation of Chiral and Achiral 1,3-Dihydro-2H-1,4-Benzodiazepin-2-ones |
| title_full | Stereoselectivity in Enzymic Biotransformation of Chiral and Achiral 1,3-Dihydro-2H-1,4-Benzodiazepin-2-ones |
| title_fullStr | Stereoselectivity in Enzymic Biotransformation of Chiral and Achiral 1,3-Dihydro-2H-1,4-Benzodiazepin-2-ones |
| title_full_unstemmed | Stereoselectivity in Enzymic Biotransformation of Chiral and Achiral 1,3-Dihydro-2H-1,4-Benzodiazepin-2-ones |
| title_short | Stereoselectivity in Enzymic Biotransformation of Chiral and Achiral 1,3-Dihydro-2H-1,4-Benzodiazepin-2-ones |
| title_sort | stereoselectivity in enzymic biotransformation of chiral and achiral 1 3 dihydro 2h 1 4 benzodiazepin 2 ones |
| url | https://www.chimia.ch/chimia/article/view/9140 |
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