Intracerebroventricular calycosin attenuates cerebral ischemia-reperfusion injury in rats via HMGB1-dependent pyroptosis inhibition

Intracerebroventricular calycosin attenuates cerebral ischemia-reperfusion injury in rats via HMGB1-dependent pyroptosis inhibition

IntroductionHMGB1-NLRP3 mediated pyroptosis was recently discovered to be a pathogenic cause of ischemic stroke. Our previous research has demonstrated the anti-inflammatory and anti-apoptotic properties of calycosin in mitigating cerebral ischemia-reperfusion injury (CIRI). However, its specific ef...

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Bibliographic Details
Main Authors: Yuhui Zhang, Qiguang Wu, Yanjin Pan, Min Xin, Wenbo Wang, Xiaoya Zhai, Peiquan Zhou, Chong Zhang, Yong Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
Subjects:
cerebral ischemia-reperfusion injury
calycosin
neuroprotection
pyroptosis
HMGB1
NLRP3
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1596087/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1596087/full

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