Interplay between tumor mutation burden and the tumor microenvironment predicts the prognosis of pan-cancer anti-PD-1/PD-L1 therapy

Interplay between tumor mutation burden and the tumor microenvironment predicts the prognosis of pan-cancer anti-PD-1/PD-L1 therapy

IntroductionImmune checkpoint inhibitors (ICIs) have revolutionized the treatment landscape for advanced cancers, yet their efficacy remains heterogeneous among patients. Tumor mutation burden (TMB) has been extensively explored as a potential biomarker for predicting ICI response. However, its appl...

Full description

Saved in:
Bibliographic Details
Main Authors: Wuyuan Liao, Xinwei Zhou, Hansen Lin, Zihao Feng, Xinyan Chen, Yuhang Chen, Minyu Chen, Mingjie Lin, Gaosheng Yao, Jinwei Chen, Haoqian Feng, Yinghan Wang, Zhiping Tan, Youyan Tan, Jun Lu, Pengju Li, Jinhuan Wei, Li Luo, Liangmin Fu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
immune checkpoint inhibitor
tumor mutation burden
tumor microenvironment
pan-cancer
biomarker
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1557461/full
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2025.1557461/full

Similar Items