Defective autophagy is a key feature of cerebral cavernous malformations

Defective autophagy is a key feature of cerebral cavernous malformations

Abstract Cerebral cavernous malformation (CCM) is a major cerebrovascular disease affecting approximately 0.3–0.5% of the population and is characterized by enlarged and leaky capillaries that predispose to seizures, focal neurological deficits, and fatal intracerebral hemorrhages. Cerebral cavernou...

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Main Authors: Saverio Marchi, Mariangela Corricelli, Eliana Trapani, Luca Bravi, Alessandra Pittaro, Simona Delle Monache, Letizia Ferroni, Simone Patergnani, Sonia Missiroli, Luca Goitre, Lorenza Trabalzini, Alessandro Rimessi, Carlotta Giorgi, Barbara Zavan, Paola Cassoni, Elisabetta Dejana, Saverio Francesco Retta, Paolo Pinton
Format: Article
Language:English
Published: Springer Nature 2015-09-01
Series:EMBO Molecular Medicine
Subjects:
autophagy
CCM
endothelial‐to‐mesenchymal transition (EndMt)
mTOR
ROS
Online Access:https://doi.org/10.15252/emmm.201505316
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https://doi.org/10.15252/emmm.201505316

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