RHOB regulates megakaryocytic and erythroid differentiation by altering the cell cycle and cytoskeleton

RHOB regulates megakaryocytic and erythroid differentiation by altering the cell cycle and cytoskeleton

Abstract RHOB, a member of the RHO GTPase family, is a target of miR-1915-3p. miR-1915-3p was proven to promote the differentiation of megakaryocytes while inhibiting that of the erythroid lineage. Although RHOB has been shown to be involved in proplatelet production in mice, its role in early haema...

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Bibliographic Details
Main Authors: Pengcong Liu, Xin Yuan, Yiming Liu, Meishan Guo, Lei Xu, Qian Dong, Tao Fan, Yang Lv, Xuetao Pei, Mingyi Qu, Wen Yue, Xiaoyan Xie
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Megakaryocytic and erythroid differentiation
RHOB
Cell cycle
Cytoskeleton
Online Access:https://doi.org/10.1038/s41598-025-95946-3
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https://doi.org/10.1038/s41598-025-95946-3

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