Characterization of shared neoantigens landscape in Mismatch Repair Deficient Endometrial Cancer

Characterization of shared neoantigens landscape in Mismatch Repair Deficient Endometrial Cancer

Abstract Endometrial cancer (EC) with Mismatch Repair deficiency (MMRd) is characterized by the accumulation of insertions/deletions at microsatellite sites. These mutations lead to the synthesis of frameshift peptides (FSPs) that represent tumor-specific neoantigens (nAg) proved to be shared across...

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Main Authors: Elisa De Paolis, Camilla Nero, Elisa Micarelli, Guido Leoni, Alessia Piermattei, Rita Trozzi, Elisa Scarselli, Anna Morena D’Alise, Luciano Giacò, Maria De Bonis, Alessia Preziosi, Gennaro Daniele, Diletta Piana, Tina Pasciuto, Gianfranco Zannoni, Angelo Minucci, Giovanni Scambia, Andrea Urbani, Francesco Fanfani
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-024-00779-4
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https://doi.org/10.1038/s41698-024-00779-4

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