Advancing CAR-based cell therapies for solid tumours: challenges, therapeutic strategies, and perspectives

Advancing CAR-based cell therapies for solid tumours: challenges, therapeutic strategies, and perspectives

Abstract Chimeric antigen receptor-cell therapies have demonstrated remarkable success in haematological malignancies but face significant hurdles in solid tumours. The hostile tumour microenvironment, antigen heterogeneity, limited tumour infiltration, and CAR-cell exhaustion contribute to reduced...

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Bibliographic Details
Main Authors: Sarkar Sardar Azeez, Raya Kh. Yashooa, Shukur Wasman Smail, Abbas Salihi, Azhin Saber Ali, Sami Mamand, Christer Janson
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Molecular Cancer
Subjects:
CAR-T cells
CAR-NK cells
CAR-Macrophages
Combination therapy
Challenges
Optimisation Strategies
Online Access:https://doi.org/10.1186/s12943-025-02386-8
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https://doi.org/10.1186/s12943-025-02386-8

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