Optimization of Lipoplexes Functionalized with a Sialic Acid Mimetic (F9-PEG) to Target the C1858T <i>PTPN22</i> Variant for Preclinical Assessment of a Novel Immunotherapy in Endocrine Autoimmunity

Optimization of Lipoplexes Functionalized with a Sialic Acid Mimetic (F9-PEG) to Target the C1858T <i>PTPN22</i> Variant for Preclinical Assessment of a Novel Immunotherapy in Endocrine Autoimmunity

<b>Background:</b> The C1858T <i>PTPN22</i> variant is strongly associated with type 1 diabetes and autoimmune thyroid disease. Current treatment is substitutive hormonal administration, which does not target the disease pathogenetic mechanism. We previously implemented a nov...

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Main Authors: Simona Sennato, Giorgia Paldino, Cecilia Bombelli, Irene Mezzani, Stefania Petrini, Domenico Vittorio Delfino, Francesco Fiorentino, Carlotta Marianecci, Alessia Ciogli, Dante Rotili, Francesca Ceccacci, Alessandra Fierabracci
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Pharmaceutics
Subjects:
type 1 diabetes
endocrine autoimmunity
immunotherapy
variant <i>PTPN22</i>
lipoplexes optimization
Online Access:https://www.mdpi.com/1999-4923/17/6/710
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