Strategies to Mitigate Cisplatin-Induced Ototoxicity: A Literature Review of Protective Agents, Mechanisms, and Clinical Gaps

Strategies to Mitigate Cisplatin-Induced Ototoxicity: A Literature Review of Protective Agents, Mechanisms, and Clinical Gaps

Background: Cisplatin, a widely used chemotherapeutic agent, is associated with significant ototoxicity, leading to progressive and irreversible sensorineural hearing loss in up to 93% of patients. Cisplatin generates reactive oxygen species (ROS) in the cochlea, activating apoptotic and necroptotic...

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Bibliographic Details
Main Authors: Alexandru Orasan, Mihaela-Cristina Negru, Anda Ioana Morgovan, Razvan Claudiu Fleser, Daniela Sandu, Adrian Mihail Sitaru, Alexandru-Catalin Motofelea, Nicolae Constantin Balica
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Audiology Research
Subjects:
cisplatin
ototoxicity
chemotherapy
antioxidants
nanoparticles
apoptosis
Online Access:https://www.mdpi.com/2039-4349/15/2/22
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