Peptide dendrimer and hyaluronic acid modified nanovesicles for ocular delivery of timolol maleate and siRNA

Peptide dendrimer and hyaluronic acid modified nanovesicles for ocular delivery of timolol maleate and siRNA

Abstract Glaucoma, a leading cause of irreversible blindness, is characterized by retinal ganglion cell (RGC) degeneration due to elevated intraocular pressure (IOP) and apoptosis. While timolol maleate effectively lowers IOP, it does not prevent RGC loss and suffers from poor corneal permeability a...

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Bibliographic Details
Main Authors: Santoshi Naik, Naitik Jain, Nagarajan Theruveethi, Srinivas Mutalik
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Glaucoma
Spanlastics
Nanovesicles
RNA interference
Peptide dendrimer
Targeted delivery
Online Access:https://doi.org/10.1038/s41598-025-10960-9
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https://doi.org/10.1038/s41598-025-10960-9

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