Discovery of 1,3-disubstituted prop-2-en-1-one derivatives as inhibitors of neutrophilic inflammation via modulation of MAPK and Akt pathways

Discovery of 1,3-disubstituted prop-2-en-1-one derivatives as inhibitors of neutrophilic inflammation via modulation of MAPK and Akt pathways

Targeting neutrophil function has gained attention as a propitious therapeutic strategy for diverse inflammatory diseases. Accordingly, a series of enone-based derivatives were developed to inhibit neutrophil-mediated inflammation, showing promise for treating inflammatory diseases. These compounds...

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Bibliographic Details
Main Authors: Mohammad Abdel-Halim, Dalia S. El-Gamil, Mennatallah A. Hammam, Mohamed El-Shazly, Yi-Hsuan Wang, Po-Hsiung Kung, Yu-Cheng Chen, Michal Korinek, Ashraf H. Abadi, Matthias Engel, Tsong-Long Hwang
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Enone derivatives
superoxide
elastase
human neutrophils
inflammation
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2024.2402988
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https://www.tandfonline.com/doi/10.1080/14756366.2024.2402988

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