Multi-Omics Analysis in Mouse Primary Cortical Neurons Reveals Complex Positive and Negative Biological Interactions Between Constituent Compounds of <i>Centella asiatica</i>

Multi-Omics Analysis in Mouse Primary Cortical Neurons Reveals Complex Positive and Negative Biological Interactions Between Constituent Compounds of <i>Centella asiatica</i>

<b>Background:</b> A water extract of the Ayurvedic plant <i>Centella asiatica</i> (L.) Urban, family Apiaceae (CAW), improves cognitive function in mouse models of aging and Alzheimer’s disease and affects dendritic arborization, mitochondrial activity, and oxidative stress...

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Main Authors: Steven R. Chamberlin, Jonathan A. Zweig, Cody J. Neff, Luke Marney, Jaewoo Choi, Liping Yang, Claudia S. Maier, Amala Soumyanath, Shannon McWeeney, Nora E. Gray
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Pharmaceuticals
Subjects:
<i>Centella asiatica</i>
triterpenes
caffeoylquinic acids
mouse primary cortical neurons
transcriptome
metabolome
Online Access:https://www.mdpi.com/1424-8247/18/1/19
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https://www.mdpi.com/1424-8247/18/1/19

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