Safety and clinical efficacy of Relmacabtagene autoleucel (relma-cel) for systemic lupus erythematosus: a phase 1 open-label clinical trialResearch in context

Summary: Background: Systemic lupus erythematosus (SLE) is a classic systemic autoimmune disease mediated by autoantibodies. Chimeric antigen receptor T (CAR-T) cell therapy, known for its success in cancer, has shown promise in achieving durable B cell depletion and long-term remission in SLE. Rel...

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Bibliographic Details
Main Authors: Jinhui Shu, Wei Xie, Chunli Mei, Anqi Ren, Sha Ke, Meilin Ma, Zisong Zhou, Yu Hu, Heng Mei
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:EClinicalMedicine
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Online Access:http://www.sciencedirect.com/science/article/pii/S2589537025001610
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