Enzyme-independent functions of HDAC3 in the adult heart

Enzyme-independent functions of HDAC3 in the adult heart

The cardioprotective effects of histone deacetylase (HDAC) inhibitors (HDIs) are at odds with the deleterious effects of HDAC depletion. Here, we use HDAC3 as a prototype HDAC to address this contradiction. We show that adult-onset cardiac-specific depletion of HDAC3 in mice causes cardiac hypertrop...

Full description

Saved in:
Bibliographic Details
Main Authors: Sichong Qian, Chen Zhang, Wenbo Li, Shiyang Song, Guanqiao Lin, Zixiu Cheng, Wenjun Zhou, Huiqi Yin, Yueli Wang, Haiyang Li, Ying H. Shen, Zheng Sun
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Histone deacetylase
Cardiac hypertrophy
Hypertrophic cardiomyopathy
HDACi
Catalytic-independent
Fatty acid oxidation
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383525003053
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

http://www.sciencedirect.com/science/article/pii/S2211383525003053

Similar Items