Mapping the extracellular molecular architecture of the pAg-signaling complex with α-Butyrophilin antibodies

Mapping the extracellular molecular architecture of the pAg-signaling complex with α-Butyrophilin antibodies

Abstract Target cells trigger Vγ9Vδ2 T cell activation by signaling the intracellular accumulation of phospho-antigen metabolites (pAgs) through Butyrophilin (BTN)-3A1 and BTN2A1 to the Vγ9Vδ2 T cell receptor (TCR). An incomplete understanding of the molecular dynamics in this signaling complex hamp...

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Main Authors: Amrita Ramesh, Sobhan Roy, Tomasz Slezak, James Fuller, Hortencia Graves, Murad R. Mamedov, Alexander Marson, Anthony A. Kossiakoff, Erin J. Adams
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-94347-w
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https://doi.org/10.1038/s41598-025-94347-w

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