Development and Validation of a Standardized Pseudotyped Virus-Based Neutralization Assay for Assessment of Anti-Nipah Virus Neutralizing Activity in Candidate Nipah Vaccines

Development and Validation of a Standardized Pseudotyped Virus-Based Neutralization Assay for Assessment of Anti-Nipah Virus Neutralizing Activity in Candidate Nipah Vaccines

<b>Background:</b> An effective vaccine against Nipah virus (NiV) is crucial due to its high fatality rate and recurrent outbreaks in South and Southeast Asia. Vaccine development is challenged by the lack of validated accessible neutralization assays, as virus culture requires BSL-4 fac...

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Main Authors: Muntasir Alam, Md Jowel Rana, Asma Salauddin, Emma Bentley, Gathoni Kamuyu, Dipok Kumer Shill, Shafina Jahan, Mohammad Mamun Alam, Md Abu Raihan, Mohammed Ziaur Rahman, Rubhana Raqib, Ali Azizi, Mustafizur Rahman
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Vaccines
Subjects:
Nipah virus
neutralizing antibody
pseudotyped virus
neutralization assay
validation
vaccine evaluation
Online Access:https://www.mdpi.com/2076-393X/13/7/753
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