Brusatol Inhibits Esophageal Squamous Cell Carcinoma Tumorigenesis Through Bad-Mediated Mitochondrial Apoptosis Induction and Anti-Metastasis by Targeting Akt1

Brusatol Inhibits Esophageal Squamous Cell Carcinoma Tumorigenesis Through Bad-Mediated Mitochondrial Apoptosis Induction and Anti-Metastasis by Targeting Akt1

Esophageal squamous cell carcinoma (ESCC) is a prevalent malignancy characterized by poor prognosis and a deficiency of effective therapies. Brusatol (Bru), a bioactive component derived from <i>Brucea javanica</i>, exhibits potent anti-tumor activity. However, the pro-apoptotic and anti...

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Bibliographic Details
Main Authors: Yao Ji, Xinxin Zhu, Yi Shi, Rui Fang, Yimeng Sun, Yurong Ruan, Liying Zhou, Yuanyuan Ge, Qichao Luo, Junyan Zhang, Junting Ma
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Biomolecules
Subjects:
Brusatol
Akt1
mitochondria apoptosis
metastasis
esophageal squamous cell carcinoma
Online Access:https://www.mdpi.com/2218-273X/15/6/812
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